ABC transporter functions as a pacemaker for sequestration of plant glucosides in leaf beetles.
Identifieur interne : 002811 ( Main/Exploration ); précédent : 002810; suivant : 002812ABC transporter functions as a pacemaker for sequestration of plant glucosides in leaf beetles.
Auteurs : Anja S. Strauss [Allemagne] ; Sven Peters ; Wilhelm Boland ; Antje BurseSource :
- eLife [ 2050-084X ] ; 2013.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Coléoptères, Glucosides.
- physiologie : Transporteurs ABC.
- Animaux.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Glucosides.
- chemical , physiology : ATP-Binding Cassette Transporters.
- metabolism : Coleoptera.
- Animals.
Abstract
Plant-herbivore interactions dominate the planet's terrestrial ecology. When it comes to host-plant specialization, insects are among the most versatile evolutionary innovators, able to disarm multiple chemical plant defenses. Sequestration is a widespread strategy to detoxify noxious metabolites, frequently for the insect's own benefit against predation. In this study, we describe the broad-spectrum ATP-binding cassette transporter CpMRP of the poplar leaf beetle, Chrysomela populi as the first candidate involved in the sequestration of phytochemicals in insects. CpMRP acts in the defensive glands of the larvae as a pacemaker for the irreversible shuttling of pre-selected metabolites from the hemolymph into defensive secretions. Silencing CpMRP in vivo creates a defenseless phenotype, indicating its role in the secretion process is crucial. In the defensive glands of related leaf beetle species, we identified sequences similar to CpMRP and assume therefore that exocrine gland-based defensive strategies, evolved by these insects to repel their enemies, rely on ABC transporters as a key element. DOI: http://dx.doi.org/10.7554/eLife.01096.001.
DOI: 10.7554/eLife.01096
PubMed: 24302568
PubMed Central: PMC3843118
Affiliations:
Links toward previous steps (curation, corpus...)
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Strauss</name><affiliation wicri:level="1"><nlm:affiliation>Department of Bioorganic Chemistry, Max Planck Institute for Chemical Ecology, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Bioorganic Chemistry, Max Planck Institute for Chemical Ecology, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Peters, Sven" sort="Peters, Sven" uniqKey="Peters S" first="Sven" last="Peters">Sven Peters</name></author><author><name sortKey="Boland, Wilhelm" sort="Boland, Wilhelm" uniqKey="Boland W" first="Wilhelm" last="Boland">Wilhelm Boland</name></author><author><name sortKey="Burse, Antje" sort="Burse, Antje" uniqKey="Burse A" first="Antje" last="Burse">Antje Burse</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:24302568</idno><idno type="pmid">24302568</idno><idno type="doi">10.7554/eLife.01096</idno><idno type="pmc">PMC3843118</idno><idno type="wicri:Area/Main/Corpus">002385</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">002385</idno><idno type="wicri:Area/Main/Curation">002385</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">002385</idno><idno type="wicri:Area/Main/Exploration">002385</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">ABC transporter functions as a pacemaker for sequestration of plant glucosides in leaf beetles.</title><author><name sortKey="Strauss, Anja S" sort="Strauss, Anja S" uniqKey="Strauss A" first="Anja S" last="Strauss">Anja S. Strauss</name><affiliation wicri:level="1"><nlm:affiliation>Department of Bioorganic Chemistry, Max Planck Institute for Chemical Ecology, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Bioorganic Chemistry, Max Planck Institute for Chemical Ecology, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Peters, Sven" sort="Peters, Sven" uniqKey="Peters S" first="Sven" last="Peters">Sven Peters</name></author><author><name sortKey="Boland, Wilhelm" sort="Boland, Wilhelm" uniqKey="Boland W" first="Wilhelm" last="Boland">Wilhelm Boland</name></author><author><name sortKey="Burse, Antje" sort="Burse, Antje" uniqKey="Burse A" first="Antje" last="Burse">Antje Burse</name></author></analytic><series><title level="j">eLife</title><idno type="ISSN">2050-084X</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ATP-Binding Cassette Transporters (physiology)</term><term>Animals (MeSH)</term><term>Coleoptera (metabolism)</term><term>Glucosides (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Coléoptères (métabolisme)</term><term>Glucosides (métabolisme)</term><term>Transporteurs ABC (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Glucosides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>ATP-Binding Cassette Transporters</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Coleoptera</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Coléoptères</term><term>Glucosides</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Transporteurs ABC</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Plant-herbivore interactions dominate the planet's terrestrial ecology. When it comes to host-plant specialization, insects are among the most versatile evolutionary innovators, able to disarm multiple chemical plant defenses. Sequestration is a widespread strategy to detoxify noxious metabolites, frequently for the insect's own benefit against predation. In this study, we describe the broad-spectrum ATP-binding cassette transporter CpMRP of the poplar leaf beetle, Chrysomela populi as the first candidate involved in the sequestration of phytochemicals in insects. CpMRP acts in the defensive glands of the larvae as a pacemaker for the irreversible shuttling of pre-selected metabolites from the hemolymph into defensive secretions. Silencing CpMRP in vivo creates a defenseless phenotype, indicating its role in the secretion process is crucial. In the defensive glands of related leaf beetle species, we identified sequences similar to CpMRP and assume therefore that exocrine gland-based defensive strategies, evolved by these insects to repel their enemies, rely on ABC transporters as a key element. DOI: http://dx.doi.org/10.7554/eLife.01096.001. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24302568</PMID><DateCompleted><Year>2015</Year><Month>03</Month><Day>06</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Print">2050-084X</ISSN><JournalIssue CitedMedium="Print"><Volume>2</Volume><PubDate><Year>2013</Year><Month>Dec</Month><Day>03</Day></PubDate></JournalIssue><Title>eLife</Title><ISOAbbreviation>Elife</ISOAbbreviation></Journal><ArticleTitle>ABC transporter functions as a pacemaker for sequestration of plant glucosides in leaf beetles.</ArticleTitle><Pagination><MedlinePgn>e01096</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.7554/eLife.01096</ELocationID><Abstract><AbstractText>Plant-herbivore interactions dominate the planet's terrestrial ecology. When it comes to host-plant specialization, insects are among the most versatile evolutionary innovators, able to disarm multiple chemical plant defenses. Sequestration is a widespread strategy to detoxify noxious metabolites, frequently for the insect's own benefit against predation. In this study, we describe the broad-spectrum ATP-binding cassette transporter CpMRP of the poplar leaf beetle, Chrysomela populi as the first candidate involved in the sequestration of phytochemicals in insects. CpMRP acts in the defensive glands of the larvae as a pacemaker for the irreversible shuttling of pre-selected metabolites from the hemolymph into defensive secretions. Silencing CpMRP in vivo creates a defenseless phenotype, indicating its role in the secretion process is crucial. In the defensive glands of related leaf beetle species, we identified sequences similar to CpMRP and assume therefore that exocrine gland-based defensive strategies, evolved by these insects to repel their enemies, rely on ABC transporters as a key element. DOI: http://dx.doi.org/10.7554/eLife.01096.001. </AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Strauss</LastName><ForeName>Anja S</ForeName><Initials>AS</Initials><AffiliationInfo><Affiliation>Department of Bioorganic Chemistry, Max Planck Institute for Chemical Ecology, Jena, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peters</LastName><ForeName>Sven</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Boland</LastName><ForeName>Wilhelm</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Burse</LastName><ForeName>Antje</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>12</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Elife</MedlineTA><NlmUniqueID>101579614</NlmUniqueID><ISSNLinking>2050-084X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018528">ATP-Binding Cassette Transporters</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005960">Glucosides</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D018528" MajorTopicYN="N">ATP-Binding Cassette Transporters</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001517" MajorTopicYN="N">Coleoptera</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005960" MajorTopicYN="N">Glucosides</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Chrysomela lapponica</Keyword><Keyword MajorTopicYN="N">Chrysomela populi</Keyword><Keyword MajorTopicYN="N">Phaedon cochleariae</Keyword><Keyword MajorTopicYN="N">RNA interference</Keyword><Keyword MajorTopicYN="N">chemical defense</Keyword><Keyword MajorTopicYN="N">fluorescence microscopy</Keyword></KeywordList><GeneralNote Owner="NLM">Original DateCompleted: 20131204</GeneralNote></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>12</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>12</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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